Our new Clear+ tissue clearing approach is the one system that delipidates samples without having change in morphology and with minimal impact on structural integrity.

Megatome can be a vibrating microtome built to portion a wide range of samples, from organoids and biopsy samples to expanded rodent brains and intact human organs. With higher blade vibrating frequency and minimized blade deflection, Megatome allows substantial-throughput tissue sectioning with uniform floor profile, together with negligible tissue damage and information loss.

Antibodies might consider weeks to diffuse via only a few millimeters of tissue, having a steep labeling gradient from surface to core.

Megatome is designed for accuracy: the blade vibrates at a higher frequency and bigger amplitude vary than other microtomes, and encompasses a one of a kind deflection Command system.

SE works by using a rotational electric powered discipline to disperse very electromobile molecules (including antibodies or surfactant micelles) all through a porous sample without harming electrically billed constructions inside the tissue. This enables 2-4 working day clearing of intact organs,

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Megatome can be a novel microtome that permits for top-precision sectioning of an array of tissue samples – from organoids, to arrays of animal organs, to intact human brain hemispheres – with small tissue harm and knowledge reduction.

eFLASH is a swift tissue labeling method which allows for uniform complete-organ staining in 20 rounds of labeling.

The SmartSPIM gentle sheet microscope offers unparalleled resolution and acquisition velocity all through intact tissue volumes, when its modular design means that you can improve and customise person parts.

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This may develop a docset named Sample in The existing directory. Docset development can be custom-made with optional arguments:

SHIELD avoids the variability of hydrogel embedding and the knowledge reduction from PFA preservation, preserving specimens for numerous rounds of processing.

Leverage the Crystal clear+ tissue clearing method, together with eFLASH and patented stochastic electrotransport technologies, to promptly apparent and label whole organs. Important highlights and characteristics include things like:

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